The Membrane Difference
Purexa™ membranes deliver modular, plug-and-play products that adapt to your priorities — whether that’s more runs, lower costs, or a simpler process from screening to commercial scale.
How it works:
Traditional resin chromatography relies on diffusion. The liquid flows through the spaces around porous beads packed tightly in a column, but target molecules must diffuse slowly into the internal pores of each bead to reach the binding sites, navigating a limited internal surface area.
Because this binding depends on slow diffusion into the beads, flow rates are constrained and residence times are long — especially for large biomolecules. The larger the molecule, the slower it diffuses, so even longer residence times are needed to achieve effective binding.
In contrast, membrane chromatography relies on convection. The liquid flows directly through large channels running through the membrane, carrying target molecules straight to accessible binding sites on the membrane surface for faster processing.
Because binding is driven by flow rather than slow, uncontrolled molecular motion, mass transfer is rapid and largely independent of molecule size. This convection-based transport enables significantly higher flow rates, shorter processing times, and consistent performance across scales.
As a result, membrane chromatography is particularly well suited for high-throughput capture and polishing of large molecules like plasmid DNA (pDNA) and mRNA.
Simple by design.
Plug & Play
Modular cassettes that drop into your existing setup.
Easy To Use
Inherently pre-packed, no incubation periods. Simple operator training.
Exact Fit
Match form factor, chemistry, and capacity to meet your exact needs.
Consistent at every scale.
The Purexa™ portfolio is designed to support every stage of development and manufacturing, from discovery through full‑scale production.
The Purexa Prep supports research and screening volumes. As the smallest of our form factors, the Prep also enables early process development and optimization, allowing for minimal buffer and consumables. Prep performance directly translates to our larger form factors, the Purexa Pilot and the Purexa Process.
The Pilot is the ideal mid‑scale solution for clinical and intermediate manufacturing volumes, while the Process is ideal for commercial production. The Process can be used by itself or seamlessly scaled by stacking up to five units at once, allowing for maximum output.
Performance is matched at each size ensuring reliable, linear scale‑up with no loss in performance across the portfolio.